Congenital or acquired uterine defects are unable to have children, life has been a part of the female regret. Recently, University of Gothenburg, Sweden Department of Obstetrics and Gynecology, Professor Mats Bruns Troon claim that their team has found the secret of successful transplantation of the uterus and has been successful in animal experiments is expected to achieve in humans within two years for uterine transplantation. If the operation is successful, it will bring good news to many infertile women, even in the near future, a man can conceive, and bear children.
Uterus transplant within two years?
Professor Mats Bruns Troon, they have successfully carried out in mice uterus transplant experiments, they took off from the healthy mice, the uterus 24 hours after transplantation back to the frozen mice, rats underwent surgery not only through natural mating pregnancy, and also successfully gave birth to their young.
In addition, the researchers also carried out on sheep and pig uterus transplant experiments, the effect is quite satisfactory. Professor Mats Bruns Trent, said in an interview: "We are the first demonstration of the uterus to nurture future generations of transplantation."
He also is expected within two years they will transplant the human uterus, which some medical experts pointed out that the bold, the object of the uterus transplantation not only women but also men.
Uterus transplant has been the world's greatest challenges the medical profession, scientists in China to establish a high degree of close relatives mouse allograft model. But scientists have not yet been achieved between the human uterus transplantation. Swedish scientists have successfully transplanted in mice, the uterus, and for the first time a smooth pregnancy and parturition, uterine transplantation research is a major breakthrough.
Asia's leading uterine transplantation in Guangzhou
October this year, the Guangdong authorities formally approved the Third Affiliated Hospital of Guangzhou Medical College conducting the "primate allogeneic transplantation of the uterus." This is the only one in Asia with a uterus transplant primates for experimental research projects.
The research team's first head, the Third Affiliated Hospital of Guangzhou Medical College, Professor Wang Yifeng experts interviewed in that the primates closest to the human body structure, if the primates successfully tested on animals, I believe that human uterine transplants will soon be realized. "Currently our research is still in preliminary stages, but we have and the University of Gothenburg, Sweden uterus transplant team to establish a long-term exchange mechanism, sharing of data and primate uterus transplant surgical experience. Our goal is an objective science in the primate allogeneic uterus transplantation in experimental animals based on, and strive to achieve human uterus transplantation. "
Currently, the project team was established in the experimental base Conghua, uterus transplant has basically overcome some of the basic aspects, such as cynomolgus monkeys has been used to build a model of postpartum hemorrhage, mastered the pelvic anatomy of primates; has launched Spirit Long the class of artificial assisted reproductive technology; with gynecological pelvic surgery and vascular anastomosis surgery experience.
Growing demand for uterine transplantation
Earlier this year, 26-year-old juan to Canton Medical Hospitals for treatment, the original, juan to adolescence has not been to menstruation, the mother took her to the hospital, an examination, doctors found juan no vagina, no uterus, the medical is called "pseudo hermaphroditism." The incidence of this disease is not high, accounting for about one-thousandth the number of gynecological clinic, but due to our large population, so the number of people converted many of them sick. Juan and normal adult women, like love, get married, although her husband had never had anything against her, but juan is very painful. Was responsible for the operation, said Wang Yi Feng, juan a "womb-derived infertility," one of the congenital condition, they either physically or psychologically very painful. The current medical technology, doctors can create an artificial vagina juan, let a normal married life, but to solve fertility problems, the only transplant the uterus.
In the UK, about 1.5 million women can not procreate uterine defects, they have about 200 people each year through a surrogate mother "by belly twins." "Right now the law is to prohibit surrogate behavior, social ethics, also opposed Surrogacy, and uterine-derived increased year by year the number of patients with infertility, uterine transplants growing demand." Professor Wang said, "womb transplant the treatment of 'infertility of uterine origin' only means, the current population in the gradual expansion of organ donation, donor shortage situation will be a certain degree of ease, the researchers transplanted uterus is necessary. "
Medical difficulties: the blood supply source instability
The patient, to accept the womb transplants will face great risks. In addition to uterine transplant is complex due to risk, women need to accept the transplant long-term use of immunosuppressive drugs to prevent organ transplant rejection phenomenon occurs.
Foreign researchers have tried to close the uterus transplants, such as the daughter of the implant body of the mother's womb, but because of surgery donors can not provide enough vascular tissue to ensure a good blood supply to the uterus, resulting in surgical failure. In 2009, British obstetrician Richard Smith announced that he had proved to be the first successful womb transplant to provide a stable source of blood supply is entirely possible to break the major technical bottlenecks of uterine transplantation.
Anti-rejection drugs is not conducive to conception
Uterus and transplant recipients, donors should be matched in the gene photogenic, so the best should be the donor uterus and uterine transplant recipients with blood of people, including mother or sister. Professor Wang said: "Today, technology has developed rapidly organ transplantation, skin transplantation, heart transplantation surgery are common, but the uterus transplant has its own specialty, surgery is not the most critical and difficult problems in the womb transplant, but that surgery After the problem. with kidney transplantation and heart transplantation, as there is also the uterus body transplant rejection, in order to prevent rejection after transplantation, the phenomenon appeared to accept the uterus transplant patients taking immunosuppressive drugs to women's needs, but the immunosuppression was have a great impact on the pregnancy will cause miscarriage or fetal congenital malformations, anti-rejection drugs and the contradiction between the current pregnancy still have not effectively resolved. "
In addition to the uterus or after transplantation to stay?
Because women need long-term use of uterine transplant anti-rejection drugs, so her having children once the uterus through the transplant, the donated uterus must be removed at the same time to accept cesarean section to reduce anti-rejection drugs she brought the long-term use side effects and other risks. Professor Wang believes that if the transplanted uterus is matched with the receptor, there is no exclusion, can keep the transplanted uterus.
Needed for the transplant surgery cost of the uterus, Professor Wang made a conservative estimate: if the donor and recipient match well, and surgery goes well, the simple cost of transplant surgery, the uterus is about the one or two million, but because of graft After the uterus need to take immunosuppressive drugs long term, and each person's physical condition is not necessarily the cost of late is difficult to estimate.
Ethical debate: man can have children it?
British "Infertility Network" organization spokeswoman Susan Xinan said: "There is no other hope for some infertile women have children, this will be an exciting good news. However, this procedure will also lead to many moral and ethical issues. "However, the Swedish expert Diaz Garcia Yabo Shi said, they studied" womb transplant "aims only to bring the Gospel to thousands of infertile women will not be trying to get men to accept and pregnant uterus transplant pregnant.
In this regard, Professor Wang said that the current pregnancy to the fact that men do not, the future is to have, difficult to give a clear answer. Of course, only from the technical point of view, men really can accept the uterus transplant. However, the uterine transplant technology and medical technology, pioneering many of the same clone, may lead to a series of moral questions of the problem. Pregnant women is a natural division of labor, while men will break the natural laws of pregnancy. "From a medical point of view, I do not advocate Nanren children, because it goes against the laws of nature. Human and social development so far, has entered into a civilized society, need some system to restrict people's behavior, but not into the disordered state. associated with the life sciences to any new technology, new inventions should first consider the optimization of the human species, and ethical issues can not be too spread use, can not change, we should not take the initiative to destroy the laws of nature. "Professor Wang said.
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